Liquid or Freeze-dried B.C.G. Vaccine

The Present Position of Freeze-Dried BCG Vaccine

I reviewed in 1952 the literature on freeze-dried BCG vaccine in order to help evaluate the relative merits of fresh liquid and dried vaccines on the basis of the results of vaccination. More BCG production centres have since taken to the preparation of dried BCG vaccine for either experimental use or for vaccination. In India, the scene of activity of the mass vaccination campaign has shifted ...

[Percutaneous or intradermal BCG vaccine?].

OBJECTIVE To compare the intradermal and percutaneous routes of BCG administration. SOURCES OF DATA A review of the literature published between 1987 and 2002 was carried out in the MEDLINE and Lilacs databases. The following key words were used: BCG vaccine/administration, adverse effects, efficacy, tuberculosis/prevention and control. Some articles published before 1987 were included becaus...

Determination of the Viability at +4°C of Freeze-Dried Attenuated Live Agalactiae Vaccine

Freeze-dried B.C.G.

Freeze-dried B.C.G. of British manufacture became available for experimental work in 1955. The main reason for introducing it was the need for a vaccine which would retain its potency under conditions of prolonged storage. On reconstitution for injection the vaccine should produce a uniform suspension with minimal clumping, resulting in a uniform viable bacterial count. These properties mean th...

Freeze-dried blood cells: therapeutic advance or laboratory curiosity?

Platelets are anucleate, cellular elements present in circulating blood that are critical for the achievement of hemostasis following tissue injury and, probably, for general maintenance of vascular integrity. The human circulation normally contains -2.5 x 108 platelets per ml, each -5 ,um3 in volume. Over the past 3 decades, much has been learned about the biochemical mechanisms and structural...